A review of the main histopathological findings in coronavirus disease 2019.
Identifieur interne : 001808 ( Main/Exploration ); précédent : 001807; suivant : 001809A review of the main histopathological findings in coronavirus disease 2019.
Auteurs : Walter O. Vasquez-Bonilla [Colombie] ; Roberto Orozco [Guatemala] ; Víctor Argueta [Guatemala] ; Manuel Sierra [Honduras] ; Lysien I. Zambrano [Honduras] ; Fausto Mu Oz-Lara [Honduras] ; Dennis Salom N L Pez-Molina [France] ; Kovy Arteaga-Livias [Pérou] ; Zachary Grimes [États-Unis] ; Clare Bryce [États-Unis] ; Alberto Paniz-Mondolfi [Venezuela] ; Alfonso J. Rodríguez-Morales [Colombie]Source :
- Human pathology [ 1532-8392 ] ; 2020.
Abstract
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.
DOI: 10.1016/j.humpath.2020.07.023
PubMed: 32750378
PubMed Central: PMC7395947
Affiliations:
- Colombie, France, Guatemala, Honduras, Pérou, Venezuela, États-Unis
- Languedoc-Roussillon, Occitanie (région administrative)
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A review of the main histopathological findings in coronavirus disease 2019.</title><author><name sortKey="Vasquez Bonilla, Walter O" sort="Vasquez Bonilla, Walter O" uniqKey="Vasquez Bonilla W" first="Walter O" last="Vasquez-Bonilla">Walter O. Vasquez-Bonilla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003</wicri:regionArea><wicri:noRegion>660003</wicri:noRegion></affiliation></author><author><name sortKey="Orozco, Roberto" sort="Orozco, Roberto" uniqKey="Orozco R" first="Roberto" last="Orozco">Roberto Orozco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala.</nlm:affiliation><country xml:lang="fr">Guatemala</country><wicri:regionArea>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001</wicri:regionArea><wicri:noRegion>01001</wicri:noRegion></affiliation></author><author><name sortKey="Argueta, Victor" sort="Argueta, Victor" uniqKey="Argueta V" first="Víctor" last="Argueta">Víctor Argueta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala.</nlm:affiliation><country xml:lang="fr">Guatemala</country><wicri:regionArea>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001</wicri:regionArea><wicri:noRegion>01001</wicri:noRegion></affiliation></author><author><name sortKey="Sierra, Manuel" sort="Sierra, Manuel" uniqKey="Sierra M" first="Manuel" last="Sierra">Manuel Sierra</name><affiliation wicri:level="1"><nlm:affiliation>Central American Technological University, Francisco Morazán, Distrito Central, Tegucigalpa, 11101 Honduras.</nlm:affiliation><country xml:lang="fr">Honduras</country><wicri:regionArea>Central American Technological University, Francisco Morazán, Distrito Central, Tegucigalpa</wicri:regionArea><wicri:noRegion>Tegucigalpa</wicri:noRegion></affiliation></author><author><name sortKey="Zambrano, Lysien I" sort="Zambrano, Lysien I" uniqKey="Zambrano L" first="Lysien I" last="Zambrano">Lysien I. Zambrano</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Department of Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras.</nlm:affiliation><country xml:lang="fr">Honduras</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Department of Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101</wicri:regionArea><wicri:noRegion>11101</wicri:noRegion></affiliation></author><author><name sortKey="Mu Oz Lara, Fausto" sort="Mu Oz Lara, Fausto" uniqKey="Mu Oz Lara F" first="Fausto" last="Mu Oz-Lara">Fausto Mu Oz-Lara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Escuela, Tegucigalpa, 11101, Honduras; Department of Internal Medicine, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras.</nlm:affiliation><country xml:lang="fr">Honduras</country><wicri:regionArea>Department of Internal Medicine, Hospital Escuela, Tegucigalpa, 11101, Honduras; Department of Internal Medicine, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101</wicri:regionArea><wicri:noRegion>11101</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Molina, Dennis Salom N" sort="L Pez Molina, Dennis Salom N" uniqKey="L Pez Molina D" first="Dennis Salom N" last="L Pez-Molina">Dennis Salom N L Pez-Molina</name><affiliation wicri:level="3"><nlm:affiliation>Institute Pasteur, Paris, 75008, France; Health Biology: Microbiology and Immunology, Faculté de Sciences, Université de Montpellier, 34000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute Pasteur, Paris, 75008, France; Health Biology: Microbiology and Immunology, Faculté de Sciences, Université de Montpellier, 34000</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Arteaga Livias, Kovy" sort="Arteaga Livias, Kovy" uniqKey="Arteaga Livias K" first="Kovy" last="Arteaga-Livias">Kovy Arteaga-Livias</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Facultad de Medicina, Universidad Nacional Hermilio Valdizán, Huánuco, 10160, Peru; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Facultad de Medicina, Universidad Nacional Hermilio Valdizán, Huánuco, 10160, Peru; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046</wicri:regionArea><wicri:noRegion>15046</wicri:noRegion></affiliation></author><author><name sortKey="Grimes, Zachary" sort="Grimes, Zachary" uniqKey="Grimes Z" first="Zachary" last="Grimes">Zachary Grimes</name><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, New York, NY, 15046</wicri:regionArea><wicri:noRegion>15046</wicri:noRegion></affiliation></author><author><name sortKey="Bryce, Clare" sort="Bryce, Clare" uniqKey="Bryce C" first="Clare" last="Bryce">Clare Bryce</name><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, New York, NY, 15046</wicri:regionArea><wicri:noRegion>15046</wicri:noRegion></affiliation></author><author><name sortKey="Paniz Mondolfi, Alberto" sort="Paniz Mondolfi, Alberto" uniqKey="Paniz Mondolfi A" first="Alberto" last="Paniz-Mondolfi">Alberto Paniz-Mondolfi</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, 1020, Venezuela; Academia Nacional de Medicina, Caracas, 1010, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, 3023, Venezuela.</nlm:affiliation><country xml:lang="fr">Venezuela</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, 1020, Venezuela; Academia Nacional de Medicina, Caracas, 1010, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, 3023</wicri:regionArea><wicri:noRegion>3023</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Morales, Alfonso J" sort="Rodriguez Morales, Alfonso J" uniqKey="Rodriguez Morales A" first="Alfonso J" last="Rodríguez-Morales">Alfonso J. Rodríguez-Morales</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, 660001, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Americas, Pereira, Risaralda, 660003, Colombia. Electronic address: arodriguezm@utp.edu.co.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, 660001, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Americas, Pereira, Risaralda, 660003</wicri:regionArea><wicri:noRegion>660003</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32750378</idno><idno type="pmid">32750378</idno><idno type="doi">10.1016/j.humpath.2020.07.023</idno><idno type="pmc">PMC7395947</idno><idno type="wicri:Area/Main/Corpus">000736</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000736</idno><idno type="wicri:Area/Main/Curation">000736</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000736</idno><idno type="wicri:Area/Main/Exploration">000736</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A review of the main histopathological findings in coronavirus disease 2019.</title><author><name sortKey="Vasquez Bonilla, Walter O" sort="Vasquez Bonilla, Walter O" uniqKey="Vasquez Bonilla W" first="Walter O" last="Vasquez-Bonilla">Walter O. Vasquez-Bonilla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003</wicri:regionArea><wicri:noRegion>660003</wicri:noRegion></affiliation></author><author><name sortKey="Orozco, Roberto" sort="Orozco, Roberto" uniqKey="Orozco R" first="Roberto" last="Orozco">Roberto Orozco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala.</nlm:affiliation><country xml:lang="fr">Guatemala</country><wicri:regionArea>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001</wicri:regionArea><wicri:noRegion>01001</wicri:noRegion></affiliation></author><author><name sortKey="Argueta, Victor" sort="Argueta, Victor" uniqKey="Argueta V" first="Víctor" last="Argueta">Víctor Argueta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala.</nlm:affiliation><country xml:lang="fr">Guatemala</country><wicri:regionArea>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001</wicri:regionArea><wicri:noRegion>01001</wicri:noRegion></affiliation></author><author><name sortKey="Sierra, Manuel" sort="Sierra, Manuel" uniqKey="Sierra M" first="Manuel" last="Sierra">Manuel Sierra</name><affiliation wicri:level="1"><nlm:affiliation>Central American Technological University, Francisco Morazán, Distrito Central, Tegucigalpa, 11101 Honduras.</nlm:affiliation><country xml:lang="fr">Honduras</country><wicri:regionArea>Central American Technological University, Francisco Morazán, Distrito Central, Tegucigalpa</wicri:regionArea><wicri:noRegion>Tegucigalpa</wicri:noRegion></affiliation></author><author><name sortKey="Zambrano, Lysien I" sort="Zambrano, Lysien I" uniqKey="Zambrano L" first="Lysien I" last="Zambrano">Lysien I. Zambrano</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Department of Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras.</nlm:affiliation><country xml:lang="fr">Honduras</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Department of Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101</wicri:regionArea><wicri:noRegion>11101</wicri:noRegion></affiliation></author><author><name sortKey="Mu Oz Lara, Fausto" sort="Mu Oz Lara, Fausto" uniqKey="Mu Oz Lara F" first="Fausto" last="Mu Oz-Lara">Fausto Mu Oz-Lara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Escuela, Tegucigalpa, 11101, Honduras; Department of Internal Medicine, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras.</nlm:affiliation><country xml:lang="fr">Honduras</country><wicri:regionArea>Department of Internal Medicine, Hospital Escuela, Tegucigalpa, 11101, Honduras; Department of Internal Medicine, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101</wicri:regionArea><wicri:noRegion>11101</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Molina, Dennis Salom N" sort="L Pez Molina, Dennis Salom N" uniqKey="L Pez Molina D" first="Dennis Salom N" last="L Pez-Molina">Dennis Salom N L Pez-Molina</name><affiliation wicri:level="3"><nlm:affiliation>Institute Pasteur, Paris, 75008, France; Health Biology: Microbiology and Immunology, Faculté de Sciences, Université de Montpellier, 34000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute Pasteur, Paris, 75008, France; Health Biology: Microbiology and Immunology, Faculté de Sciences, Université de Montpellier, 34000</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Arteaga Livias, Kovy" sort="Arteaga Livias, Kovy" uniqKey="Arteaga Livias K" first="Kovy" last="Arteaga-Livias">Kovy Arteaga-Livias</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Facultad de Medicina, Universidad Nacional Hermilio Valdizán, Huánuco, 10160, Peru; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Facultad de Medicina, Universidad Nacional Hermilio Valdizán, Huánuco, 10160, Peru; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046</wicri:regionArea><wicri:noRegion>15046</wicri:noRegion></affiliation></author><author><name sortKey="Grimes, Zachary" sort="Grimes, Zachary" uniqKey="Grimes Z" first="Zachary" last="Grimes">Zachary Grimes</name><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, New York, NY, 15046</wicri:regionArea><wicri:noRegion>15046</wicri:noRegion></affiliation></author><author><name sortKey="Bryce, Clare" sort="Bryce, Clare" uniqKey="Bryce C" first="Clare" last="Bryce">Clare Bryce</name><affiliation wicri:level="1"><nlm:affiliation>Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Icahn School of Medicine at Mount Sinai, New York, NY, 15046</wicri:regionArea><wicri:noRegion>15046</wicri:noRegion></affiliation></author><author><name sortKey="Paniz Mondolfi, Alberto" sort="Paniz Mondolfi, Alberto" uniqKey="Paniz Mondolfi A" first="Alberto" last="Paniz-Mondolfi">Alberto Paniz-Mondolfi</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, 1020, Venezuela; Academia Nacional de Medicina, Caracas, 1010, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, 3023, Venezuela.</nlm:affiliation><country xml:lang="fr">Venezuela</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, 1020, Venezuela; Academia Nacional de Medicina, Caracas, 1010, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, 3023</wicri:regionArea><wicri:noRegion>3023</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Morales, Alfonso J" sort="Rodriguez Morales, Alfonso J" uniqKey="Rodriguez Morales A" first="Alfonso J" last="Rodríguez-Morales">Alfonso J. Rodríguez-Morales</name><affiliation wicri:level="1"><nlm:affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, 660001, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Americas, Pereira, Risaralda, 660003, Colombia. Electronic address: arodriguezm@utp.edu.co.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, 660001, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Americas, Pereira, Risaralda, 660003</wicri:regionArea><wicri:noRegion>660003</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human pathology</title><idno type="eISSN">1532-8392</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32750378</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-8392</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>02</Day></PubDate></JournalIssue><Title>Human pathology</Title><ISOAbbreviation>Hum. Pathol.</ISOAbbreviation></Journal><ArticleTitle>A review of the main histopathological findings in coronavirus disease 2019.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0046-8177(20)30147-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.humpath.2020.07.023</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vasquez-Bonilla</LastName><ForeName>Walter O</ForeName><Initials>WO</Initials><AffiliationInfo><Affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orozco</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Argueta</LastName><ForeName>Víctor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sierra</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Central American Technological University, Francisco Morazán, Distrito Central, Tegucigalpa, 11101 Honduras.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zambrano</LastName><ForeName>Lysien I</ForeName><Initials>LI</Initials><AffiliationInfo><Affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Department of Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muñoz-Lara</LastName><ForeName>Fausto</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Escuela, Tegucigalpa, 11101, Honduras; Department of Internal Medicine, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Molina</LastName><ForeName>Dennis Salomón</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Institute Pasteur, Paris, 75008, France; Health Biology: Microbiology and Immunology, Faculté de Sciences, Université de Montpellier, 34000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arteaga-Livias</LastName><ForeName>Kovy</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Facultad de Medicina, Universidad Nacional Hermilio Valdizán, Huánuco, 10160, Peru; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimes</LastName><ForeName>Zachary</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bryce</LastName><ForeName>Clare</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paniz-Mondolfi</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Icahn School of Medicine at Mount Sinai, New York, NY, 15046, USA; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, 1020, Venezuela; Academia Nacional de Medicina, Caracas, 1010, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, 3023, Venezuela.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Morales</LastName><ForeName>Alfonso J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia; Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, 15046, Peru; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, 660001, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Americas, Pereira, Risaralda, 660003, Colombia. Electronic address: arodriguezm@utp.edu.co.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hum Pathol</MedlineTA><NlmUniqueID>9421547</NlmUniqueID><ISSNLinking>0046-8177</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autopsy</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Histopathology</Keyword><Keyword MajorTopicYN="N">Pathology</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32750378</ArticleId><ArticleId IdType="pii">S0046-8177(20)30147-7</ArticleId><ArticleId IdType="doi">10.1016/j.humpath.2020.07.023</ArticleId><ArticleId 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